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    Erie Community College
  Jan 16, 2018
Fall 2017 Catalog [ARCHIVED CATALOG]

ML 124 - Serology Lab

Credit Hours: 1.5

A course which presents the basic immunologic concepts as they relate to laboratory diagnosis/treatment/prevention of disease. Fundamental mechanisms of the immune system and immunologically-related diseases will be incorporated. The underlying principles of currently used serologic procedures of clinical significance will be discussed. A research paper/poster and oral presentation is required.

Course Outcomes
Upon completion of this course, the student will be able to:

  • describe the four basic types of immunity: innate, adaptive, humoral and cellular;
  • describe the Major Histocompatibility Complex (MHC) and HLA and their role in the immune system;
  • describe the various cells involved in the immune response;
  • discuss antibody (immunoglobulin) structure and function;
  • discuss the mechanisms of the specific immune response;
  • discuss the mechanisms of the nonspecific immune response;
  • recognize the four types of hypersensitivity reactions;
  • discuss the types of autoimmunity and the theories involved;
  • discuss and categorize immunodeficiency;
  • discuss transplantation and its effects on the immune response;
  • discuss the nature of antigens;
  • discuss antigen-antibody binding;
  • describe the various types of reactions involving precipitation and discuss how they are used;
  • describe reactions involving agglutination, inhibition of agglutination and how they are used;
  • describe assays using complement;
  • describe the immunologic method of immunofluorescence and how it is used;
  • describe other serologic testing methods, i.e. PCR, RFLP, chemiluminescence, NAT, etc.;
  • discuss syphilis and other spirochete disease and describe the testing methods used in diagnosis;
  • discuss streptococcal serology and describe testing methods used in diagnosis;
  • discuss the serology of viral infections: Epstein-Barr, Rubella, Herpes, Hepatitis A, C, D, and E and describe testing methods used for diagnosis;
  • discuss HIV serology and describe testing methods used in diagnosis; and
  • describe the serologic testing methods used for the diagnosis of autoimmune disease.

Prerequisites: CH 180, CH 181, and ML 112
S (N)