Apr 01, 2020  
Spring 2019 Catalog 
Spring 2019 Catalog [ARCHIVED CATALOG]

ML 124 - Serology Lab

Credit Hours: 1.0

A course which presents the basic immunologic concepts as they relate to laboratory diagnosis, treatment and prevention of disease. Fundamental mechanisms of the immune system and immunologically-related diseases will be incorporated. The underlying principles of currently used serologic procedures of clinical significance will be discussed. A research paper/poster and oral presentation is required.

Course Outcomes
Upon completion of this course, the student will be able to:

  • describe the four basic types of immunity: innate, adaptive, humoral and cellular;
  • describe the Major Histocompatibility Complex (MHC) and Human Leukocyte Antigens (HLA) and their roles in the immune system;
  • describe the various cells involved in the immune response;
  • discuss antibody (immunoglobulin) structure and function;
  • discuss the mechanisms of the specific immune response;
  • discuss the mechanisms of the nonspecific immune response;
  • recognize the four types of hypersensitivity reactions;
  • discuss the types of autoimmunity and the theories involved;
  • discuss and categorize immunodeficiency;
  • discuss transplantation and its effects on the immune response;
  • discuss the nature of antigens;
  • discuss antigen-antibody binding;
  • describe the various types of reactions involving precipitation and discuss how they are used;
  • describe reactions involving agglutination, inhibition of agglutination and how they are used;
  • describe assays using complement;
  • describe the immunologic method of immunofluorescence and how it is used;
  • describe other serologic testing methods, i.e. polymerase chain reaction (PCR), restriction fragment length polymorphism (RFLP), chemiluminescence, NAT, etc.;
  • discuss syphilis and other spirochete disease and describe the testing methods used in diagnosis;
  • discuss streptococcal serology and describe testing methods used in diagnosis;
  • discuss the serology of viral infections: Epstein-Barr, Rubella, Herpes, Hepatitis A, C, D, and E and describe testing methods used for diagnosis;
  • discuss Human Immunodeficiency Virus (HIV) serology and describe testing methods used in diagnosis; and
  • describe the serologic testing methods used for the diagnosis of autoimmune disease

Prerequisites: CH180, CH181, and ML112
S (N)