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Dec 07, 2024
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Spring 2020 Catalog [ARCHIVED CATALOG]
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ML 124 - Serology Lab Credit Hours: 1.0
A course which presents the basic immunologic concepts as they relate to laboratory diagnosis, treatment and prevention of disease. Fundamental mechanisms of the immune system and immunologically-related diseases will be incorporated. The underlying principles of currently used serologic procedures of clinical significance will be discussed. A research paper/poster or oral presentation is required.
Course Outcomes Upon completion of this course, the student will be able to:
- describe the four basic types of immunity: innate, adaptive, humoral and cellular;
- describe the Major Histocompatibility Complex (MHC) and Human Leukocyte Antigens (HLA) and their roles in the immune system;
- describe the various cells involved in the immune response;
- discuss antibody (immunoglobulin) structure and function;
- discuss the mechanisms of the specific immune response;
- discuss the mechanisms of the nonspecific immune response;
- recognize the four types of hypersensitivity reactions;
- discuss the types of autoimmunity and the theories involved;
- discuss and categorize immunodeficiency;
- discuss transplantation and its effects on the immune response;
- discuss the nature of antigens;
- discuss antigen-antibody binding;
- describe the various types of reactions involving precipitation and discuss how they are used;
- describe reactions involving agglutination, inhibition of agglutination and how they are used;
- describe assays using complement;
- describe the immunologic method of immunofluorescence and how it is used;
- describe other serologic testing methods, i.e. polymerase chain reaction (PCR), restriction fragment length polymorphism (RFLP), chemiluminescence, NAT, etc.;
- discuss syphilis and other spirochete disease and describe the testing methods used in diagnosis;
- discuss streptococcal serology and describe testing methods used in diagnosis;
- discuss the serology of viral infections: Epstein-Barr, Rubella, Herpes, Hepatitis A, C, D, and E and describe testing methods used for diagnosis;
- discuss Human Immunodeficiency Virus (HIV) serology and describe testing methods used in diagnosis; and
- describe the serologic testing methods used for the diagnosis of autoimmune disease.
Prerequisites: CH180, CH181, and ML112 S (N)
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